We then explored the tradition hallmark pathways in COAD or KIRC, including tumor_inflammation_signature, cellular_response_to_hypoxia, tumor_proliferation_signature, EMT_markers, ECM-related_genes, angiogenesis, apoptosis, DNA_repair, G2M_checkpoint, inflammatory_response, PI3K_AKT_mTOR_pathway, P53_pathway, MYC_targets, TGFB, IL-10_anti-inflammatory_signaling_pathway, genes_upregulated_by_reactive_oxygen_species_(ROS), DNA_replication, collagen_formation, and degradation_of_ECM. This evidence concerns the gene TGFB1 and neoplasm.