We analyzed the pro-inflammatory HIF1α target genes IL1β, IL6, Nos2 and the anti-inflammatory gene IL10. In the absence of infection, we detected an increase of IL1β and a decrease in IL10, when comparing normoxia versus hypoxia (Figure 8), which is in line with the observation that the HIF pathway regulates cytokine production in multiple cell types (Malkov et al., 2021). The gene discussed is IL6; the disease is infection.