Furthermore, KEGG and REACTOME enrichment analysis also demonstrated that the highly expressed DEGs in DBTRG mainly concentrated in the pathways that correlated with tumor invasion, e.g., ECM−receptor interaction, extracellular matrix organization, degradation of the extracellular matrix, collagen formation, collagen biosynthesis and modifying enzymes, crosslinking of collagen fibrils, collagen chain trimerization, and signaling pathways such as MAPK and mTOR pathways (Supplementary Figures S4A,B). This evidence concerns the gene MTOR and neoplasm.