SLC7A5 (L-type amino acid transporter 1 or LAT1) forms heterodimer with SLC3A2 to function as a Na+ independent, large neutral amino acid antiporter (Kanai et al., 1998; Mastroberardino et al., 1998) that is commonly overexpressed in cancer cells (Kanai, 2022). The gene discussed is SLC7A5; the disease is cancer.