SLC7A5 and osteosarcoma: In addition, SLC7A5 has been verified as a direct target for miR-328-3p, whereas the reduction of LAT1 protein levels by miR-328-3p in osteosarcoma cells does not alter the overall levels of AAs (Yi et al., 2020), highlighting the importance to examine the impact on substrate transport or balance and indicating the presence of complex regulatory network behind AA homeostasis.