Multiple system atrophy Human cases from University of California San Diego Alzheimer Disease Research Center 5 transgenic mouse models (MBP1-hαsyn tg, MBP29-hαsyn tg, mThy1-hαsyn tg, mThy1-hAPP tg, mThy1-htau) and non-transgenic mice. Here, TG is linked to early-onset autosomal dominant Alzheimer disease.