To determine the extent to which LKB1 can regulate tumor matrix remodeling and fully identify a role for LKB1–stromal interactions in breast cancer tumorigenesis and metastasis, we utilized a model of tissue decellularization and our previously generated and validated MDA-MB-231-LKB1 overexpressing cell line (Rhodes et al., 2015). Here, STK11 is linked to neoplasm.