While collagen type I is well described as having a role in cancer cell proliferation, drug resistance, and motility (Barcus et al., 2017; Liu et al., 2018; Lovitt et al., 2018), the matrix proteins such as COL3A1, COL11A1, FBN1, and MFAP2 are less explored in breast cancer. This evidence concerns the gene COL3A1 and breast cancer.