IGFBP4 and neoplasm: The expression of positive regulators of adipogenesis (COL6A2, IL7RB, and IGFBP4) (M. Lee et al., 2015; Maridas et al., 2017; Oh et al., 2021) was increased when MDA-MB-231 cells were seeded on the tumor scaffold compared to MDA-MB-231 cells seeded on the adipose scaffolds.