MDA-MB-231 cells seeded on the tumor scaffold had an overall increase in the expression of collagen proteins, including major fiber collagens (COL1A1, COL1A2, and COL3A1), fat-related collagen (COL6A2), and glycoproteins (DPT, FBN1, IGFBP4, MFAP2) when compared to MDA-MB-231 cells seeded on the adipose scaffold, while LKB1 had reduced expression of these proteins on both adipose and tumor scaffolds. This evidence concerns the gene COL6A2 and neoplasm.