Interestingly, in patients with AD, proinflammatory cytokines, including IL-1b, IL6, and TNF-α, are particularly elevated through Aβ stimulating microglia (Murphy et al., 1998; Liu and Hong, 2003; Ye et al., 2013; Wood et al., 2015; Barroeta-Espar et al., 2019) and disrupt the homeostasis of immune system in the CNS, which may cause direct result in sleep disturbance seen in patients with AD. The gene discussed is IL6; the disease is Alzheimer disease.