Proinflammatory cytokines, including IL-1b, IL6, and TNF-alpha, are elevated in cultured neurons derived from patients with AD (Murphy et al., 1998; Liu and Hong, 2003; Ye et al., 2013; Wood et al., 2015; Barroeta-Espar et al., 2019). The gene discussed is IL1B; the disease is Alzheimer disease.