NLRP3 and obesity due to melanocortin 4 receptor deficiency: Chronic conditions of inflammation, often seen with advancing age, and in co-morbidities including hypertension (Tziomalos and Athyros, 2015), coronary artery disease (Roy et al., 2021) and obesity (Qin et al., 2021), are all risk factors for the onset of kidney disease, where NLRP3 activation is pivotal to pathology (Menini et al., 2020).