NLRP3 and glomerulosclerosis: Similarly, NLRP3 inhibition in db/db mice improved morphological parameters (mesangial expansion, glomerular hypertrophy, glomerulosclerosis and tubulointerstitial damage) and decreased disease biomarkers (serum creatinine, urinary albumin to creatinine ratio), further corroborating the beneficial effects of reducing inflammasome activation in the diabetic kidney (Zhang et al., 2019).