A link between NLRP3 inflammasome activity and glomerular injury in the kidneys of people with diabetic nephropathy is now well established (Shahzad et al., 2015), with evidence that increased glomerular NLRP3 expression (Shahzad et al., 2015; Hou et al., 2020) is paralleled by elevated levels of serum IL1β, the latter of which exhibits a positive correlation to albuminuria (Shahzad et al., 2015). The gene discussed is NLRP3; the disease is diabetic kidney disease.