Wang et al. found that silencing KCNQ1OT1, a ceRNA that promotes inflammatory injury in AKI, could indirectly inhibit NLRP3 inflammasomes through targeted activation of miRNA-204-5p to ameliorate IRI-induced inflammatory injury in renal tubular epithelial cells (Wang J. et al., 2021). The gene discussed is NLRP3; the disease is acute kidney injury.