Zhang et al. found that human umbilical cord mesenchymal stem cell-derived exosome treatment indirectly caused the inhibition of NF-κB activity by up-regulating the level of miRNA-146b in renal tubular epithelial cells, thereby alleviating sepsis-induced AKI (Zhang R. et al., 2020). This evidence concerns the gene NFKB1 and acute kidney injury.