Our cohort of beta-thalassemia carriers, in contrast to previously studied groups (Selek et al., 2007), also exhibits higher than average extracellular antioxidant capacity, as well as superior intracellular equilibrium of redox metabolites (e.g., increased urate, decreased s-allantoin) (Tzounakas et al., 2022), irrespectively to the variable degree of beta-globin synthesis imposed by the heterozygous state of β++ and β+ underlying mutations. This evidence concerns the gene HBB and beta thalassemia.