ET-1 (the major isoform of endothelins) and VEGFA, which have been both reported to play a key role in the pathogenesis of atherosclerosis, cardiovascular disease and stroke, may provide potential novel therapeutic targets (Shibuya, 2015; Jung et al., 2016; Barton and Yanagisawa, 2019). The gene discussed is EDN1; the disease is stroke disorder.