CLOCK and depressive disorder: Given the comorbidity of circadian rhythm disruption and neuropsychiatric conditions like depression, anxiety, substance abuse, and neurodegenerative disease (Ketchesin et al., 2020), it is tempting to speculate that a disruption of the striatal circadian clock may play a causal role, potentially by its interaction with components of the dopamine signaling pathway (Kim et al., 2017).