Importantly, the loss of one copy of Gpr88 did not affect anxiety- or depressive-like behaviors displayed in the elevated plus-maze test (Supplementary Figures 2A,C), open field test (Supplementary Figure 2D), marble-burying test (Supplementary Figure 3A) or tail suspension test (Supplementary Figure 3B) (Table 2). Here, GPR88 is linked to Anxiety.