In addition, Spp1, which encodes secreted phophoprotein 1, and Cytokeratins (Krt7, Krt8, Krt18), both implicated in several kidney pathologies, among them renal cell carcinoma (RCC), found also to increase immediately after induction of the injury and remained upregulated till day 4, when they lowered to the normal levels. Here, KRT8 is linked to renal cell carcinoma.