The hydrolyzed protein–iron complex showeda significant decrease in the anemic condition in caco-2 cells byreducing the mRNA levels of marker genes (divalent metal transporter-1(DMT1), transferrin receptor (TFR), and ankyrin repeat domain 37 (ANKRD37))that were induced by iron deficiency anemia.157 Gómez et al. hydrolyzed red tilapia viscera to obtain proteinhydrolysate having iron-chelating activity. The gene discussed is ANKRD37; the disease is anemia.