TFRC and neoplasm: It has been shown that when the nanoparticle shellsare combinedwith targeting molecules, the active nanoparticles can enhance affinityand binding ability to tumor cells via receptor-mediated endocytosis.6,7 Functional ligand-conjugated polymers achieve higher efficiencyin drug delivery due to the selective recognition of specific markerson tumor cell membranes, including epidermal growth factor receptors,integrins, transferrin receptors, integrins, etc.8−11 In recent years, the field ofαvβ3 integrin-mediated bioactivetumor targeting has been explored extensively.