EZH2 and osteosarcoma: Zhang et al. (2018b) identified that MALAT1 regulates the expression of β-catenin and E-cadherin via the MALAT1/EZH2 axis which in turn changes the gene expression downstream of β-catenin. In another latest study, MALAT1 was also found to serve as a ceRNA network for HDAC4 (histone deacetylase 4), where it regulates osteosarcoma proliferation and apoptosis by upregulating HDAC4 via decoying miR-140-5p (Sun and Qin, 2018).