Its unique expression pattern in osteosarcoma, regulation of DNA methylation, exploiting chromatin remodelers, functioning via ceRNA network, and also promising outcomes in other cancers; all of these shows a great potential for HOTAIR to be an excellent candidate for epigenetic therapeutics in osteosarcoma (Cantile et al., 2020; Li et al., 2017b). This evidence concerns the gene HOTAIR and osteosarcoma.