DNMT1 and osteosarcoma: Several miRNAs expression has also been associated with abnormal methylation that could be targeted with DNMT inhibitors to suppress osteosarcoma progression (e.g., miR-485-3p, miR-370, miR-142, miR-7, miR-129-5p) (Ding et al., 2015; Du et al., 2018; Long et al., 2015; Zhang and Peng, 2017; Zhang et al., 2019).