Several miRNAs have been reported to be involved in the Notch signaling pathway in the initiation and progression of osteosarcoma, of which some are tumor suppressor miRNAs such as miR-26a (targets Jagged1), miR-1296-5p (targets Notch2), miR-34 and miR-200 (targets Notch1) and some play oncogenic role for example, miR-10b-5p (targets NCOR2) (Lei et al., 2020; Xia et al., 2020). This evidence concerns the gene NCOR2 and osteosarcoma.