CDKN2B-AS1 and osteosarcoma: The epigenetic crosstalk between ANRIL and the microRNAs was first documented in gastric cancer (Zhang et al., 2014a), its overexpression affects osteosarcoma cell proliferation, invasion, apoptosis (Cheng et al., 2017; Yu et al., 2018) and metastasis (Guan et al., 2018).