E2F5 and neoplasm: miR-154-5p acts as tumor suppressor in osteosarcoma and its upregulation inhibits the proliferation, migration and invasion in vitro as well as in-vivo tumor growth via the dysregulation in the pro-apoptotic proteins’ expression and the cell cycle regulators such as E2F5, Cyclin E1 and CDK2 (Tian et al., 2018).