A novel interplay between lncRNA HOTAIR, miR-126, and DNA methylation in osteosarcoma has been reported by Li et al. (2017b), where they found that HOTAIR can repress CDKN2A gene expression through DNA hypermethylation by suppressing miR-126 expression (a negative regulator of DNMT1). Here, DNMT1 is linked to osteosarcoma.