Few other miRNAs have been found targeting the histone modifying enzymes such as HDAC4 or Sirtuin-1 and thus inhibiting proliferation, migration, invasion and epithelial-mesenchymal transition of osteosarcoma cells, for example, miR-126, miR-133b, miR-204 (Liao et al., 2021; Shi et al., 2017; Tang et al., 2017; Ying et al., 2017). The gene discussed is HDAC4; the disease is osteosarcoma.