It can be inferred from our results that the upstream oncogene THSD7A not only affected the mTOR, extracellular signal-regulated kinase (ERK), and adenosine monophosphate-activated protein kinase (AMPK) signaling pathways but might also upregulate the expression of SCARA5 to promote cancer in ESCC [24]. Here, THSD7A is linked to esophageal squamous cell carcinoma.