We found that APOH was involved in the regulation of “LXR/RXR activation” and “cute phase response signaling.” HLA-DQA2 played a key role in “MSP-RON signaling in macrophage pathway” and “systemic lupus erythematosus in T cell signaling pathway.” Furthermore, EGF was also related to many pathways, such as “breast cancer regulation by Stathmin1,” “HER-2 signaling in breast cancer,” and “CREB signaling in neurons” (Supplementary Table 62). This evidence concerns the gene CREB1 and breast cancer.