By the way, PTGS2 is considered a specific biomarker of ferroptosis, and its encoded protein COX-2 can catalyze the metabolism of PUFAs, especially arachidonic acid (AA), into prostaglandin isoforms PGE2, thereby bridging the cross talk between pain and ferroptosis in prostatitis [24, 25]. The gene discussed is PTGS2; the disease is urogenital neoplasm.