In 2019, national cohort of children with renal disease from 13 different regions of China were recruited from 2014 to 2018, ADCK4, WT1 and NPHS1 were the top three commonly mutated genes in the SRNS group with mutation rates of 5.7, 5.4, and 2.8%, respectively (17). The gene discussed is NPHS1; the disease is kidney disorder.