The pathogenesis of MG is mediated by multiple pathogenic antibodies, such as acetylcholine receptor antibody (AChR-Ab), muscle-specific kinase antibody (Musk-Ab), low density lipoprotein receptor-related protein 4 antibody (LRP4-Ab), different cytokines, and complement activation pathways (4). This evidence concerns the gene LRP4 and myasthenia gravis.