NPPB and endothelial dysfunction: In addition, cardiac biomarkers (26) such as troponin, high-sensitivity troponin, BNP, cardiac enzymes, and other potential biomarkers such as those for endothelial dysfunction, myocardial ischemia, oxidative stress and inflammation should be evaluated for a comprehensive assessment to achieve early real-time identification, assessment, and monitoring of cardiotoxicity, and timely targeted treatment.