Additionally, the pairwise comparison of ROC curves did not show a significant difference between the IgM and APGL-I values for CAR-TP and HHC but APGL-I performance showed sensitivity and specificity of 38.4 and 100%, respectively, for untreated HD patients (p = 0.0002, respectively) (Table 2). The gene discussed is CD40LG; the disease is Huntington disease.