(X2 = 45.8; p < 0.001; R2 MacFadden = 0.49; Accuracy = 0.88; Specificity = 0.927; Sensitivity = 0.80; AUC = 0.915), Patients with positive anti-Mce1A IgM titers had a 3.6 chance [OR = 3.6 (95% CI = 1.1–11.6); p = 0.028] and anti-Mce1A IgA titer had a 2.3 chance [OR = 2.3 (95% CI = 1.2–4.3); p = 0.005] of being diagnosed with HD compared to healthy volunteers. Here, CD40LG is linked to Huntington disease.