The evidence manifested that the mRNA level of PBMC m6A demethylases ALKBH5 positively correlated with that of RNA-binding protein YTHDF2 in patients with AS, which is consistent with the data from Yang et al. (28) and our previous study in systemic lupus erythematosus (SLE) (29). The gene discussed is ALKBH5; the disease is systemic lupus erythematosus.