Other miRNA’s that negatively regulate NLRP3 protein expression are miR-22-3p, miR-133b-3p, miR-186-5p, and miR-495-3p which have been studied in a variety of disease states including asthma, AD, allergic inflammation, cardiac microvascular endothelial cell injury (CMEC) and more (Xiao et al., 2017; Chen M. L. et al., 2018; Zhou et al., 2018; Han et al., 2020; Guo et al., 2021). Here, NLRP3 is linked to Alzheimer disease.