NLRP3 and Parkinson disease: NLRP3 deficient mice are resistant to the loss of dopaminergic neurons in the substantia nigra after treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin that induces a PD-like phenotype (Yan et al., 2015; Lee E. et al., 2019).