TNF and rheumatoid arthritis: Similarly, pharmacological inhibition of the NLRP3 inflammasome with different inhibitors reduces RA pathology and secretion of IL-1β and TNF-α, supporting the involvement of NLRP3 in RA (Yan et al., 2012; Voon et al., 2017; Guo et al., 2018; Marchetti et al., 2018b).