Transgenic mice lacking NLRP3 fed with a high-fat diet, which has previously been shown to activate NLRP3, have lower IL-1β and are protected from high-fat diet-induced insulin resistance, further supporting inflammatory mediators’ involvement in metabolic inflammation and insulin resistance (Vandanmagsar et al., 2011; Wen et al., 2011). Here, NLRP3 is linked to Insulin resistance.