Zhan et al. (2020) found that PD enhances the neuronal differentiation of bone marrow mesenchymal stem cells and promotes functional recovery through Nrf2 activation, indicating that this is a promising new method for the treatment of spinal cord injury. In addition, Yang et al. (2016) found that BMSC combined with plumbagin can alleviate SCI through its anti-oxidative stress, inflammation, apoptosis and activation of the Nrf2 pathway. This evidence concerns the gene NFE2L2 and Parkinson disease.