Chen et al. (2019) revealed that NaHS exerts anti-injury and anti-inflammatory effects by activating the Nrf2/HO-1 pathway. Wang (2010) clarified the physiological role of H2S in neurological diseases. Xu et al. (2021) found that H2S showed neuroprotective effects on SCI model rats, improved nerve injury symptoms, reduced inflammatory factor secretion, nerve cell apoptosis, etc., which were achieved by activating the Nrf2 pathway. Here, NFE2L2 is linked to nervous system disorder.