Lv et al. (2019) studied the mechanism of PD alleviating SCI in rats. Studies have shown that PD may inhibit oxidative stress and apoptosis by regulating the Nrf2/HO-1 signal pathway of microglia, thereby protecting the spinal cord from SCI. Zhan et al. (2021) exposed spinal cord motor neurons (SMNs) to OGD/R environment to establish a spinal cord ischemia/reperfusion injury (SCII) model, which was treated with different doses of PD at different times. The gene discussed is HMOX1; the disease is Parkinson disease.