Heat-shock protein family A (Hsp70) member 4 (HSPA4) was involved in the functional stabilization of mutated or aberrantly expressed genes in multiple tumors (Lv et al., 2012) and had been identified to have a significant correlation with immune regulation and prognosis of hepatocellular carcinoma (Shang et al., 2021). Here, HSPA4 is linked to hepatocellular carcinoma.