GMDS and neoplasm: Notably, as the sole protective NRG for LUAD, CYLD Lysine 63 Deubiquitinase (CYLD) had been considered as the tumor suppressor and further demonstrated to be regulated by miR-96-5p and LncRNA GMDS-AS1 to inhibit the development of LUAD via a cellular assay and mouse tumor models (Zhao et al., 2020).