Interestingly, we also compared their expression levels between tumor and normal tissues and found that the expressional changes were complex, especially significantly upregulated genes (CDKN2A, MYCN, PLK1, and TERT) and some downregulated signatures (AXL, ID1, and TLR3) (Figure 1D, Supplementary Table S3). This evidence concerns the gene MYCN and neoplasm.