As an acute phase protein, ORM1 has the ability to induce monocytes to release IL-1, TNF-α, IL-6, and IL-12 (Ligresti et al., 2012), and a multivariate classification model using the six proteins, including ORM1, predicts responses to NAC and further predicts relapse-free survival of BC patients (Hyung et al., 2011). The gene discussed is TNF; the disease is breast cancer.