VARS2 and familial dilated cardiomyopathy: By Reactome pathway analysis, expression of majority of genes of mitochondrial aminoacyl-tRNA-synthetases was downregulated in DCM hearts, including Aars2, Cars2, Farsb, Fars2, Hars2, Lars2, Mars2, Nars2, Ppa2, Rars2, Tars2, and Vars2 (Figure 3B).