Experimentally, genetic models with enhanced Hippo pathway (i.e., Mst1-TG) (Yamamoto et al., 2003; Nguyen et al., 2019; Wu et al., 2021) or knockout (KO) of genes of the pathway downstream transcription factors YAP (yes-associated protein) (Xin et al., 2013) or TEAD1 (TEA-domain family member 1) (Liu et al., 2017; Liu et al., 2021), all developed similar DCM phenotypes. The gene discussed is MST1; the disease is familial dilated cardiomyopathy.