In DCM hearts, there was a strong trend of downregulation for majority of genes that code components of the system (Figures 7B,C), including key subunits of TOM complex (Tomm17/20/22/40/70), TIM complex (Timm8b/10/17/21/22/23/44/50) and Samm50 (Figure 7B). The gene discussed is TIMM8B; the disease is familial dilated cardiomyopathy.