SSTR4 and depressive disorder: A study by Scheich et al. revealed that activation of SSTR4 in the central nervous system plays a role in modulation of behavioral responses to acute stress and neuroendocrine changes induced by mild chronic stress in mice, suggesting involvement of SSTR4 in anxiety and depression-like behavior (Scheich et al., 2016; Scheich et al., 2017), consistent with our research.