Among other diseases with immune involvement, co-inheritance of KIR3DL1 and HLA-Bw4, or specific HLA-Bw4 alleles, has been associated with protection from multiple sclerosis (Hollenbach et al., 2016) and ankylosing spondylitis (Hanson et al., 2020), and both KIR3DL1-HLA-Bw4 and KIR2DL3-HLA-C1 co-inheritance with protection from autoimmune hepatitis (Littera et al., 2016). This evidence concerns the gene KIR3DL1 and multiple sclerosis.