In a recent functional investigation of the link between topoisomerase-I (TOP1) derived peptides and HLA-DR alleles in 6 ATA + SSc patients, a restricted and shared set of TOP1 peptides were eluted off HLA-DR molecules from patient monocyte-derived dendritic cells pulsed with recombinant human TOP1. The gene discussed is TOP1; the disease is systemic sclerosis.