The majority of immune cells were negatively correlated with the risk score, especially hematopoietic stem cells of XCELL, tumor-related fibroblasts, stroma score, granulocyte-monocyte progenitor cells, and activated mast cells of CIBERSORT-ABS, resting memory CD4 + T cells, M2 macrophages, and Treg cells of QUANTISEQ and myeloid dendritic cells and endothelial cells of MCPCOUNTER (Figure 7A). Here, CD4 is linked to neoplasm.