LDLR and familial hyperaldosteronism: In male hyperlipidemic Ldlr-knockout mice (phenocopy of homozygous FH which PCSK9 loss-of-function has little effect) of the same age, BE3-Angptl3 showed higher efficiency (as compared to the BE3 control), with 56% reduction in triglycerides, and 51% reduction in cholesterol levels (Chadwick et al., 2018).