Moreover, the relationship between Reptin and genomic heterogeneity, including Neoantigen (NEO), tumor mutational burden (TMB), microsatellite instability (MSI), DNA mismatch repair (MMR) genes, methyltransferase, RNA modification genes, and related signaling pathways were also evaluated to search for the possible biological mechanism of Reptin in the prognosis or immune within various cancer types. This evidence concerns the gene RUVBL2 and cancer.