Figure 4B displays the case number, types, and sites of the Reptin genetic variants. In short, missense mutation of Reptin was the primary type. Additionally, we explored the possible association between alterations of Reptin and the prognosis of various cancer patients. The results demonstrated that Reptin had no difference in OS between the patients with genetic alterations and patients without alterations (Figure 4C). The gene discussed is RUVBL2; the disease is cancer.