Herein, we analyzed TCGA data and found that HAVCR1 was overexpressed in tumor tissues of Pancreatic adenocarcinoma, Liver hepatocellular carcinoma, Esophageal carcinoma and Stomach adenocarcinoma compared to normal tissue, suggesting HAVCR1 is an important risk factor in these tumors and could serve as a prognostic biomarker. Here, HAVCR1 is linked to carcinoma of esophagus.