On the other hand, variants in the IFIH1 gene were also causative of the Aicardi-Goutieres syndrome (AGS-7; OMIM 615846), an autosomal dominant inflammatory disorder characterized by severe neurologic impairment such as progressive encephalopathy, spastic paraplegia, and calcification of basal ganglia (Crow et al., 2015). This evidence concerns the gene IFIH1 and Aicardi-Goutieres syndrome.