TP53 and cancer: In addition, cell adhesion (GO:0098632; GO:0007156; GO:0005912; p < 0.05), protein kinase activity (GO:0004672, p = 0.024), and cytoskeleton (GO:0015629, p = 0.004; GO:0045104, p = 0.008; GO:0032970, p = 0.003) were all significantly enriched again (Figure 7A) While 87 marker genes were functionally enriched in epithelial–mesenchymal transition (Hallmark: M5930, p = 0.035), the P53 pathway (Hallmark: M5939, p = 0.020) and proteoglycans in cancer (KEGG:hsa05205, p < 0.001) are indispensable signals for metastasis of PDAC.