Notably, HMGB3 showed significant relationships with tumor-associated CD8+ T cell, CD4+ T cell, T cell regulatory, NK cell, B cell, and dendritic cell infiltrating levels, implying that HMGB3 was favorably related to tumor-associated immune cell infiltration in the CTC microenvironment (All p value < 0.05) (Figures 9K–P). Here, CD4 is linked to neoplasm.