PPARA and metabolic dysfunction-associated steatohepatitis: Moreover, in a recent study with several in vitro cell models of NASH/NAFLD, including HepG2, HepaRG, and hepatic cells obtained from the skin of human stem cell (hSKP-HPC), primary human hepatocytes (PHH), and LX-2 cells, numerous PPARα agonists, such as fenofibrate, showed a decrease in the induction of these cell culture-based models of NASH [87].