Regarding GLP-1 and its influences on reward processing through globus pallidus, ventral tegmental area and nucleus accumbens could explain detected association of GIPR rs1800437 and social anxiety scores, since neural activation in globus pallidus, among others, is associated with social phobia and anxiety disorders (Hattingh et al., 2013; Suchankova et al., 2015; Ashworth et al., 2021). The gene discussed is GLP1R; the disease is anxiety disorder.