After FDR correction, we observed a striking pattern of association whereby only SST rCTPs were negatively associated with each tau and beta-amyloid-related neuropathology–most strongly with neuritic plaques (pFDR = 3.1 × 10–4)–and positively associated with rates of cognitive decline (pFDR = 3.9 × 10–6) and cognition measured proximal to death (pFDR = 5.7 × 10–5) (Figure 3). This evidence concerns the gene MAPT and Mental deterioration.