Overall, all of these studies suggested that propolis and its constituents inhibit cell proliferation, survival, and cell cycle by altering various signaling pathways (PI3K/Akt, MAPK, TNF-α/NF-κB, Wnt/β-catenin, and STAT-3/PLK-1) in several cancers (Figure 2). This evidence concerns the gene NFKB1 and cancer.