Overall, the studies have found that propolis and its constituents inhibit cell migration, epithelial-to-mesenchymal transition, and tumor metastasis by regulating several signaling molecules such as growth factors (EGF, VEGF, PDGF, HIF-1, and FGF), EMT markers (vimentin, E-cadherin, β-catenin, and Snail), and metastatic-related proteins (MMPs, uPA, and interleukin). Here, HIF1A is linked to neoplasm.