The results displayed notably increased expression level of p-NF-κB, p-IKBα, p-P38, and p-ERK and higher ratios of p-NF-κB/NF-κB, p-IKBα/IKBα, p-P38/P38, and p-ERK/ERK in the renal tissue of CRS rats compared with those of the Sham group (P < 0.01). The gene discussed is NFKB1; the disease is congenital rubella syndrome.