Moreover, the 9 effective targets of MLD, including PTGS2, CHRM5, BCL, PRKCA, SOD1, CAT, NOS2, IL1B, and IL1A, were enriched in pathways of the neurodegeneration-multiple disease (hsa05022, as shown in Figure 7). The gene discussed is SOD1; the disease is metachromatic leukodystrophy.