Further, due to the complexity of the adenosinergic actions in the CNS and diverse and wide distributions of A1R and A2AR across brain regions (O'Brien, 1988; Chen et al., 2014; Fredholm et al., 2005; Chen et al., 2013), the application of adenosinergic interventions to prevent SUDEP deserves deeper discussion. Here, ADORA2A is linked to Sudden unexpected death in epilepsy.