The NTS level of ADK (Figures 2B,C) was altered by Adk mutation and IHKA-modeled epilepsy (genotype factor, p < 0.0001 F(1,18) = 189.2; modeling factor, p = 0.0012, F(1,18) = 14.69; interaction, p = 0.002, F(1,18) = 22.21; two-way ANOVA, n = 5–6 per group). The gene discussed is ADK; the disease is epilepsy.