The disrupted adenosinergic system, e.g., altered densities of A1R, A2AR, and the adenosine metabolic enzyme, adenosine kinase (ADK) were also seen in different brain areas in patients with temporal lobe epilepsy (TLE) and correlated to SUDEP risk (Patodia et al., 2020). This evidence concerns the gene ADK and temporal lobe epilepsy.