ADORA2A and epilepsy: Furthermore, NTS A2AR level was altered by IHKA epilepsy vs. sham controls (p < 0.0001, F(1,18) = 166.5, modeling factor, two-way ANOVA, n = 5-6 per group), in both epileptic Adk+/- and WT mice vs. their corresponding sham controls (p < 0.0001 and p < 0.0001, unpaired t-test) (Figures 3A,B).