ADORA2A and epilepsy: For instance, adenosine A1 and A2A receptors (A1R and A2AR) are identified to express on synapses in limbic cortical areas (Tetzlaff et al., 1987; Rebola et al., 2003a; Rebola et al., 2005a; Rebola et al., 2005b); an increased A2AR density and a decreased A1R density are shown at excitatory terminals of different limbic areas from animal models of epilepsy and patients with epilepsy (Rebola et al., 2003b; Rebola et al., 2005c; He et al., 2020).