BCL2L11 and esophageal squamous cell carcinoma: Our data showed that knockdown of Bim significantly alleviated the percentage of apoptotic cells induced by celastrol (Figure 5B and Supplementary Figure S1E), along with a reduction of the c-PARP (Figure 5C), demonstrating that Bim was involved in celastrol-induced intrinsic apoptosis of ESCC cells.