NR1H4 and exocrine pancreatic carcinoma: Consistent with these results, Lee et al. (Lee et al., 2011) reported that downregulation of FXR in pancreatic carcinoma cells decreases NF-κB activity and consequently inhibits its target genes, indicating that NF-κB may participate in the regulation of FXR activity (Gadaleta et al., 2011), involving a positive crosstalk mechanism.