In addition, many de novo mutations related to neurological diseases, such as epilepsy and developmental delay, are associated with the pre-M1 regions of both GluN1 and GluN2 subunits, which also appear to affect the kinetics of the channels (Sobolevsky et al., 2007; Ogden et al., 2017; Vyklicky et al., 2018; XiangWei et al., 2019; McDaniel et al., 2020). This evidence concerns the gene GRIN1 and Global developmental delay.