Amazedly, a steady stream of evidence confirmed that aconitine can block the current of IKr, composed of α subunit HERG and β subunit MiRP1, by intercepting the HERG channel, causing the prolonged cardiac APD and arrhythmia (Abbott et al., 1999; Wang S. et al., 2020). The gene discussed is KCNH2; the disease is cardiac arrhythmia.