Substantial evidence has indicated that the PI3K/Akt signaling pathway, MAPK signaling pathway, cytokine-cytokine receptor interaction, and cGMP/PKG signaling pathway are related to vasculopathy (Wang et al., 2013; Karar and Maity, 2011; Loppnow et al., 2011; Zhou et al., 2021). This evidence concerns the gene PIK3CA and vascular disorder.