Specifically, CREB5 has been shown to promote cell proliferation and correlate with a poor prognosis in hepatocellular carcinoma, while the lncRNA SNHG5 affects the cell proliferation, metastasis, and migration of colorectal cancer through regulating miR-132–3p/CREB5 (Wu et al., 2018). This evidence concerns the gene CREB5 and hepatocellular carcinoma.