Previous studies have reported that LCA induces the disruption of phospholipid/sphingolipid homeostasis through TGF-β signaling, and the decrease of LysoPC and SM levels was related to the elevated lysophosphatidylcholine acyltransferase (LPCAT) and sphingomyelin phosphodiesterase (SMPD) expression (Matsubara et al., 2011). The gene discussed is SMPD1; the disease is Leber congenital amaurosis.