Previous studies have reported that LCA induces the disruption of phospholipid/sphingolipid homeostasis through TGF-β signaling, and the decrease of LysoPC and SM levels was related to the elevated lysophosphatidylcholine acyltransferase (LPCAT) and sphingomyelin phosphodiesterase (SMPD) expression (Matsubara et al., 2011). This evidence concerns the gene TGFB1 and Leber congenital amaurosis.