KEGG enrichment analysis indicated that the signaling pathways of Shema against COPD were mainly related with oxidative phosphorylation, focal adhesion, DNA replication, regulation of actin cytoskeleton, Fc gamma R-mediated phagocytosis, B cell receptor signaling pathway, PPAR signaling pathway, ECM-receptor interaction, Fc epsilon RI signaling pathway, and fatty acid degradation (Figure 3D). Here, PPARA is linked to chronic obstructive pulmonary disease.